Geriatrics & Aging

Cellular mechanism in Aging

Aging can be defined as a condition of progressive functional decline with increased mortality. Accumulation of time-dependent cell damage, i.e. DNA damage and mutations and incorrectly folded proteins, can damage organs and cellular function. The accumulation of molecular damage together with modifications in the epigenetic landscape, regulation of genetic expression, and altered endocrine communication, drive the aging process and establish age as the main risk factor for age-associated diseases and molecular damage.